Absorption of I125-labeled homologous albumin by rat kidney proximal tubule cells. A study of microperfused single proximal tubules by electron microscopic autoradiography and histochemistry. 1966.
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منابع مشابه
Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase.
Receptor-mediated endocytosis of albumin is an important function of the kidney proximal tubule epithelium. We have measured endocytosis of [125I]-albumin in opossum kidney cells and examined the regulation of this process by phosphatidylinositide 3-kinase (PI 3-kinase). Albumin endocytosis was inhibited by both wortmannin (IC50 6.9 nM) and LY294002 (IC50 6.5 microM) at concentrations that sugg...
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The formation of protein absorption droplets in the cells of the proximal convolution was studied in mouse kidney. Ox hemoglobin was administered intraperitoneally and kidney specimens were collected at intervals of 30 minutes to 4 days after injection. In the lumen of the nephron, hemoglobin was concentrated to an opaque mass whose relations with the brush border and the epithelium could be ea...
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15 صفحه اولKidney Proximal Tubules
The aim of this study was to evaluate the role of the kidney in mediating the signals involved in adaptive changes in luminal Na+/H+ exchange and basolateral Na+:HCOcotransport systems in metabolic acidosis. Proximal tubular suspensions were prepared from rabbit kidney cortex and incubated in acidic (A) or control (C) media (pH 6.9 vs 7.4, 5% C02) for 2 h. Brush border membrane (BBM) and basola...
متن کاملInulin and Albumin Absorption from the Proximal Tubule in Necturus Kidney.
In the kidney of the amphibian, Necturus, appreciable quantities of inulin and human serum albumin are transported from the tubular lumen of the proximal tubules into the blood. These findings suggest that inulin may not be a satisfactory indicator for measuring net water movement in the kidney of this species.
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1997
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v82323